Acyl hydrazides as peptoid sub-monomers

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acyl hydrazides as peptoid sub-monomers.

The use of acyl hydrazides as peptoid sub-monomers is investigated. We demonstrate here that azapeptoids derived entirely from acyl hydrazides can be made conveniently and efficiently using standard peptoid sub-monomer chemistry. Structural studies reveal that the main chain amide bond in these molecules predominantly adopts a trans conformation. A high-quality one bead one compound library of ...

متن کامل

Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.

In this communication we describe a novel strategy for the formation of valuable diaryl and aryl alkyl ketones from acyl hydrazides. A wide variety of ketones are prepared and the mild reaction conditions allow for the use of a range of functionalities, especially in the synthesis of diaryl ketones.

متن کامل

Peptoid helicity modulation: precise control of peptoid secondary structures via position-specific placement of chiral monomers.

The degree of peptoid helicity can be effectively modulated by position-specific incorporation of α-chiral aromatic monomers. In this study, we report the structural role of each monomer position collected from 30 comprehensive model peptoid oligomers demonstrating a meticulous manner to fine-tune peptoid secondary structures.

متن کامل

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions.

The 1,3,4-oxadiazole is an aromatic heterocycle valued for its low-lipophilicity in drug development. Substituents at the 2- and/or 5-positions can modulate the heterocycle's electronic and hydrogen bond-accepting capability, while exploiting its use as a carbonyl bioisostere. A new approach to 1,3,4-oxadiazoles is described wherein α-bromo nitroalkanes are coupled to acyl hydrazides to deliver...

متن کامل

Dendrimer hydrazides as multivalent transient inter-cellular linkers.

Three-dimensional (3D) multi-cellular aggregates (MCAs), as a model scaffold-free tissue construct, are useful for engineering cell-dense and matrix-poor tissues for repair and regeneration applications. To facilitate rapid MCA formation with high degrees of linker consistency and performance, we synthesized a class of dendrimer hydrazides with 8, 16 and 32 arms that can react with the aldehyde...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chemical Communications

سال: 2011

ISSN: 1359-7345,1364-548X

DOI: 10.1039/c1cc12750k